Hitting a dead end in the caves of Mewgenics usually means one thing: the Wall of Flesh. This pulsing barrier blocks progression and cannot be broken by normal attacks or abilities. To move forward, players must obtain a key item called the Throbbing Gristle.
This guide explains where to get the Throbbing Gristle, how to defeat the boss that drops it, and how to use it to open the Wall of Flesh so exploration can continue.
What Is the Wall of Flesh?
The Wall of Flesh acts as a mid-game progression gate inside the cave system. After spending enough time exploring underground, players eventually encounter this biological barrier that completely blocks the path forward.
There is no way to destroy it, bypass it with skills, or skip it through alternate routes. The game requires players to engage with the house event system before progressing deeper into the caves. In short, the Throbbing Gristle is mandatory for moving forward.
Wall of Flesh location
How to Get Throbbing Gristle
To obtain the Throbbing Gristle in Mewgenics, players must return home and trigger house events. The item drops from a specific boss encounter.
Defeat Guillotina
The boss that drops the Throbbing Gristle is Guillotina. This enemy appears during house events, which rotate randomly as players progress through runs.
If Guillotina does not appear immediately, players simply need to continue cycling through house events. The boss pool rotates, so persistence is required.
Before starting the fight, it helps to prepare the team properly. While Guillotina is not the hardest boss in Mewgenics, entering the fight without upgraded cats, solid abilities, or proper positioning can lead to unnecessary losses.
Guillotina boss fight
How to Use Throbbing Gristle
Once Guillotina is defeated and the Throbbing Gristle is obtained, opening the Wall of Flesh is simple.
Players should return to the cave location where the Wall of Flesh was discovered. Stand directly in front of the barrier and press the interaction button, usually E on keyboard or the equivalent button on controller.
There is no need to equip the item or activate it from a menu. The Throbbing Gristle triggers automatically upon interaction with the wall. After use, the item is consumed.
Because it is a single-use item, players should consider saving before interacting. The areas beyond the Wall of Flesh introduce stronger enemies and tougher encounters.
What Unlocks After the Wall
Passing through the Wall of Flesh expands the cave system and opens new areas filled with additional enemies, items, and progression opportunities. It marks a clear shift into the next stage of the game.
Players should expect tougher fights and more complex encounters beyond this point, so preparation matters.