How to Unlock All Mutations in Grounded 2

Mutations in Grounded 2 transform your tiny survivor into a specialized powerhouse. These ability enhancements reward dedicated playstyles and unlock game-changing bonuses that can mean the difference between thriving and barely surviving in Brookhollow Park. Whether you're perfecting your Assassin dagger techniques or mastering the Natural Explorer speed buffs, understanding how to unlock and optimize these mutations is essential for serious players.

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What Are Mutations?

Mutations function as permanent character upgrades that you earn through specific gameplay challenges. Each mutation has three progressive phases, with rewards becoming more powerful as you advance. You start with just two active mutation slots, but can expand to a maximum of five slots using Milk Molars - those valuable collectibles scattered throughout the world.

The mutation system divides into four distinct categories:

Fighting Style Mutations

Lil Fist

This mutation transforms bare-knuckle fighting into a viable combat strategy. While punching bugs might seem counterintuitive, this mutation builds up devastating charged attacks:

• Kill 40/100/200 creatures with fists
• Target grubs for easy early progression

Smasher

This mutation enhances club weapons with bonus stun effects, perfect for controlling larger threats like roaches and praying mantises:

• Kill 40/100/200 creatures with clubs
• Pairs excellently with Guard Dog for base defense

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Blademaster

This mutation makes sword combat incredibly effective by reducing enemy damage output and removing stamina limitations during combat:

• Kill 40/100/200 creatures with swords
• The temporary stamina removal allows for extended combo chains

Assassin

This mutation caters to stealth players who prefer dual daggers and sickles:

• Kill 40/100/200 creatures with daggers
• Critical hit bonuses make this mutation devastating for dash strikes

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Sharpshooter

This mutation rewards patient archers with increased critical hit chances on fully charged shots:

• Kill 40/100/200 creatures with bows
• Maintain distance for maximum effectiveness

Javelineer

This mutation enhances spear combat with throwing damage bonuses and damage reflection:

• Kill 40/100/200 creatures with spears
• Counter-attacks reflect damage back to attackers

Whittle Wizard

This mutation amplifies staff elemental effects, making Sizzle burns more intense and frozen enemies more vulnerable:

• Kill 40/100/200 creatures with staves
• Critical hit chances increase against enemies with maximum elemental buildup

Combat Abilities Mutation

Parry Master

Parry Master transforms perfect blocking into a stamina recovery tool:

• Perform 30/80/150 perfect blocks
• Practice timing against predictable enemies first

Ambush

Ambush rewards stealth gameplay with critical hit bonuses against unaware enemies:

• Land 30/80/150 ambush attacks
• Combines perfectly with Assassin for devastating stealth builds

Frenzy

With Frenzy, melee attacks trigger rage. You deal increased damage and regenerate health while enraged, but you cannot time your blocks. This is unlocked after completing the main story objectives and defeating the stranger.

• Defeat the mysterious stranger

Guard Dog

Guard Dog specifically enhances base defense during MIX.R events:

• Complete 1/4/9 MIX.R events
• Essential for players who prioritize base building

Exploration Mutations

Natural Explorer

Provides speed bonuses that make traversal significantly faster:

• Discover 20/50/80 points of interest
• Speed boost temporarily reduces after combat engagement

Trapper Peep.r

Increases critical hit damage multipliers through creature knowledge:

• Collect 25/50/75 gold cards
• Enhanced understanding of enemy weaknesses

Survival Mutations

Cardio Fan

Addresses stamina management, which is one of the most common player struggles:

• Deplete stamina 100/250/500 times
• Faster stamina recovery and reduced exhaustion duration

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Fresh Defense

Rrequires consuming mint shards for elemental protection:

• Eat 1/5/10 mint shards
• Reduces Sizzle burn rate and poison gas damage

Spicy Safety

Provides essential cold resistance for Ice Cream Cart exploration:

• Eat 1/5/10 spicy shards
• Stack with cold-resistant armor and warming smoothies

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Reliable Fan

Enhances revival speed for multiplayer teams:

• Revive 5/15/30 allies
• Significantly reduces downtime during difficult encounters

Mithridatism

Mithridatism provides venom resistance against poisonous creatures:

• Kill 5/50/150 venomous creatures
• Essential for Spider and scorpion encounters

The mutation system rewards dedicated players who commit to mastering specific playstyles. Whether you prefer the surgical precision of Assassin builds or the elemental mastery of Whittle Wizard combinations, these permanent upgrades provide the foundation for surviving Brookhollow Park's escalating challenges.